Poster Presentation Society of Obstetric Medicine of Australia and New Zealand ASM 2018

NSAID-Induced acute kidney injury in the post-partum period - A case series (#50)

Karmen Lim 1 , Penny Wolski 2 , Renuka Sekar 2 , Ann-Maree S Craven 2
  1. Greenslopes Private Hospital, Brisbane, Qld, Australia
  2. Royal Brisbane and Womens Hospital, HERSTON, QLD, Australia

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic class of medications in the post-partum period. In the general population, NSAIDs have a variable rate of adverse renal effects from 1-5%. This risk is highest in people with pre-existing kidney diseases, illnesses such as sepsis or hypovolaemia, or concommitant use of diuretics and ACE Inhibitors. There has been no study investigating the risk of NSAID-induced AKI specifically in the post-partum period. We present three cases of previously healthy women who developed post-partum AKI most likely due to regular anti-inflammatory use. None of the patients had any known risk factor for NSAID-induced AKI and the duration of NSAID use was less than 7 days in each case. This series highlights the lack of knowledge of the rate of NSAID induced AKI in post-partum patients. Given the liberal use of this medication in the post-partum period, further investigation is required.